Glycomics: A pathway to a class of new and improved therapeutics

被引：164

作者：

Shriver, Z

Raguram, S

Sasisekharan, R

机构：

[1] MIT, Biol Engn Div, Cambridge, MA 02139 USA

[2] Momenta Pharmaceut, Cambridge, MA 02138 USA

[3] Parivid Corp, Cambridge, MA 02142 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd1521

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Complex glycans that are located at the surface of cells, deposited in the extracellular matrix and attached to soluble signalling molecules have a crucial role in the phenotypic expression of cellular genotypes. However, owing to their structural complexity and some redundancy in terms of structures that elicit a function, the therapeutic potential of complex glycans has not been well exploited, with a few notable exceptions. This review outlines recent advances that promise to increase our ability to use complex glycans as therapeutics. Opportunities for the development of further structure-function relationships for these complex molecules are also discussed.

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收藏

页码：863 / 873

页数：11

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