A Dimeric Sesquiterpenoid from a Malaysian Meiogyne as a New Inhibitor of Bcl-xL/BakBH3 Domain Peptide Interaction

被引：41

作者：

Litaudon, Marc ^{[1
]}

Bousserouel, Hadjira ^{[1
]}

Awang, Khalijah ^{[2
]}

Nosjean, Olivier ^{[3
]}

Martin, Marie-Therese ^{[1
]}

Dau, Marie Elise Tran Huu ^{[1
]}

Hadi, Hamid A. ^{[2
]}

Boutin, Jean A. ^{[3
]}

Sevenet, Thierry ^{[1
]}

Gueritte, Francoise ^{[1
]}

机构：

[1] CNRS, UPR2301, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[2] Univ Malaya, Dept Chem, Kuala Lumpur 59100, Malaysia

[3] Inst Rech Servier, F-78290 Croissy Sur Seine, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 03期

关键词：

BCL-XL; BCL-X(L);

D O I：

10.1021/np8006292

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In an effort to find potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on 1470 Malaysian plant extracts. The ethyl acetate extract obtained from the bark of Meiogyne cylindrocarpa was selected for its interaction with the Bcl-xL/Bak association. Bioassay-guided purification of this species led to the isolation of two new dimeric sesquiterpenoids (1 and 2) possessing an unprecedented substituted cis-decalin carbon skeleton. Meiogynin A (1) showed the strongest activity with a K-i of 10.8 +/- 3.1 mu M.

引用

页码：480 / 483

页数：4

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