Chromosome damage and progression into and through mitosis in vertebrates

被引:33
作者
Morrison, C
Rieder, CL
机构
[1] Natl Univ Ireland Galway, NCBES, Dept Biochem, Galway, Ireland
[2] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Div Mol Med, Lab Cell Regulat, Albany, NY 12201 USA
关键词
DNA repair; mitosis-spindle assembly checkpoint; DNA damage checkpoint; G2/M; p38;
D O I
10.1016/j.dnarep.2004.03.005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
How cells behave as they divide in the presence of chromosome (DNA) damage is only just beginning to be explored. It appears to depend on the cell type and organism, the stage of development, how extensive the damage is and when it occurs. The existing data support the conclusion that vertebrate somatic cells lack a conventional DNA damage checkpoint during mitosis, and that when damaged DNA does prolong mitosis it is mediated by the spindle assembly checkpoint. As a rule, in the presence of DNA damage cells ultimately undergo an aberrant mitosis and enter the ensuing G1. They then either die, via apoptosis or mitotic catastrophe, or survive with an altered genome. To avoid these outcomes, cells with DNA damage are normally prevented from entering mitosis by a number of G2 checkpoint control pathways. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1133 / 1139
页数:7
相关论文
共 76 条
[21]   Mitotic repression of the transcriptional machinery [J].
Gottesfeld, JM ;
Forbes, DJ .
TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (06) :197-202
[22]   Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation [J].
Griffin, CS ;
Simpson, PJ ;
Wilson, CR ;
Thacker, J .
NATURE CELL BIOLOGY, 2000, 2 (10) :757-761
[23]  
GUPTA RS, 1985, JNCI-J NATL CANCER I, V74, P159
[24]   Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1 [J].
Hagting, A ;
den Elzen, N ;
Vodermaier, HC ;
Waizenegger, IC ;
Peters, JM ;
Pines, J .
JOURNAL OF CELL BIOLOGY, 2002, 157 (07) :1125-1137
[25]   HUMAN WEE-1 MAINTAINS MITOTIC TIMING BY PROTECTING THE NUCLEUS FROM CYTOPLASMICALLY ACTIVATED CDC2 KINASE [J].
HEALD, R ;
MCLOUGHLIN, M ;
MCKEON, F .
CELL, 1993, 74 (03) :463-474
[26]   Topoisomerase II poisoning by ICRF-193 [J].
Huang, KC ;
Gao, HL ;
Yamasaki, EF ;
Grabowski, DR ;
Liu, SJ ;
Shen, LL ;
Chan, KK ;
Ganapathi, R ;
Snapka, RM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (48) :44488-44494
[27]   Centrosomes split in the presence of impaired DNA integrity during mitosis [J].
Hut, HMJ ;
Lemstra, W ;
Blaauw, EH ;
van Cappellen, GWA ;
Kampinga, HH ;
Sibon, OCM .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (05) :1993-2004
[28]  
Jha MN, 2002, RADIAT RES, V157, P26, DOI 10.1667/0033-7587(2002)157[0026:CEGRIG]2.0.CO
[29]  
2
[30]   The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition [J].
Kang, DM ;
Chen, J ;
Wong, J ;
Fang, GW .
JOURNAL OF CELL BIOLOGY, 2002, 156 (02) :249-259