Chromosome damage and progression into and through mitosis in vertebrates

被引:33
作者
Morrison, C
Rieder, CL
机构
[1] Natl Univ Ireland Galway, NCBES, Dept Biochem, Galway, Ireland
[2] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Div Mol Med, Lab Cell Regulat, Albany, NY 12201 USA
关键词
DNA repair; mitosis-spindle assembly checkpoint; DNA damage checkpoint; G2/M; p38;
D O I
10.1016/j.dnarep.2004.03.005
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
How cells behave as they divide in the presence of chromosome (DNA) damage is only just beginning to be explored. It appears to depend on the cell type and organism, the stage of development, how extensive the damage is and when it occurs. The existing data support the conclusion that vertebrate somatic cells lack a conventional DNA damage checkpoint during mitosis, and that when damaged DNA does prolong mitosis it is mediated by the spindle assembly checkpoint. As a rule, in the presence of DNA damage cells ultimately undergo an aberrant mitosis and enter the ensuing G1. They then either die, via apoptosis or mitotic catastrophe, or survive with an altered genome. To avoid these outcomes, cells with DNA damage are normally prevented from entering mitosis by a number of G2 checkpoint control pathways. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:1133 / 1139
页数:7
相关论文
共 76 条
[31]   Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5 [J].
Kapoor, TM ;
Mayer, TU ;
Coughlin, ML ;
Mitchison, TJ .
JOURNAL OF CELL BIOLOGY, 2000, 150 (05) :975-988
[32]   The many substrates and functions of ATM [J].
Kastan, MB ;
Lim, DS .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2000, 1 (03) :179-186
[33]   CENTRIOLE DISTRIBUTION DURING TRIPOLAR MITOSIS IN CHINESE-HAMSTER OVARY CELLS [J].
KERYER, G ;
RIS, H ;
BORISY, GG .
JOURNAL OF CELL BIOLOGY, 1984, 98 (06) :2222-2229
[34]   Functional interaction between DNA-PK and c-Abl in response to DNA damage [J].
Kharbanda, S ;
Pandey, P ;
Jin, SF ;
Inoue, S ;
Bharti, A ;
Yuan, ZM ;
Weichselbaum, R ;
Weaver, D ;
Kufe, D .
NATURE, 1997, 386 (6626) :732-735
[35]   ACTIVATION OF THE C-ABL TYROSINE KINASE IN THE STRESS-RESPONSE TO DNA-DAMAGING AGENTS [J].
KHARBANDA, S ;
REN, RB ;
PANDEY, P ;
SHAFMAN, TD ;
FELLER, SM ;
WEICHSELBAUM, RR ;
KUFE, DW .
NATURE, 1995, 376 (6543) :785-788
[36]   Centrosome-independent mitotic spindle formation in vertebrates [J].
Khodjakov, A ;
Cole, RW ;
Oakley, BR ;
Rieder, CL .
CURRENT BIOLOGY, 2000, 10 (02) :59-67
[37]   Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions [J].
Kraakman-van der Zwet, M ;
Overkamp, WJI ;
van Lange, REE ;
Essers, J ;
van Duijn-Goedhart, A ;
Wiggers, I ;
Swaminathan, S ;
van Buul, PPW ;
Errami, A ;
Tan, RTL ;
Jaspers, NGJ ;
Sharan, SK ;
Kanaar, R ;
Zdzienicka, MZ .
MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (02) :669-679
[38]   CELL LINE-SPECIFIC DIFFERENCES IN THE CONTROL OF CELL-CYCLE PROGRESSION IN THE ABSENCE OF MITOSIS [J].
KUNG, AL ;
SHERWOOD, SW ;
SCHIMKE, RT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (24) :9553-9557
[39]   DNA-SYNTHESIS AND MULTINUCLEATION OF MOUSE CELLS INFECTED WITH SV40 IN THE PRESENCE OF CYTOCHALASIN-B [J].
KURIMURA, T ;
HIRANO, A .
JOURNAL OF GENERAL VIROLOGY, 1980, 46 (JAN) :237-242
[40]   Characterization of the p53-dependent postmitotic checkpoint following spindle disruption [J].
Lanni, JS ;
Jacks, T .
MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (02) :1055-1064