Effects of glucagon, insulin, amylin and CGRP on feeding

The roles of the pancreatic peptides glucagon, insulin, and amylin in the inhibitory control of feeding are reviewed. Calcitonin gene-related peptide (CGRP) is also included because it is structurally and functionally related to amylin and because known amylin and CRRP receptors are activated by both peptides.(1) Glucagon-like peptide 1, in contrast, is structurally distinct from pancreatic glucagon and does not cross-react with glucagon receptors, so it is not considered.(2) Several detailed reviews of the feeding effects of these peptides have appeared recently;(3-8) where appropriate, these are cited rather than the primary literature. (C) 1999 Harcourt Publishers ltd.