Involvement of periostin-sclerostin-Wnt/β-catenin signaling pathway in the prevention of neurectomy-induced bone loss by naringin

被引：46

作者：

Lv, Jianwei ^{[1
,2
]}

Sun, Xiaolei ^{[1
]}

Ma, Jianxiong ^{[1
]}

Ma, Xinlong ^{[1
,2
]}

Xing, Guosheng ^{[1
]}

Wang, Ying ^{[1
]}

Sun, Lei ^{[1
]}

Wang, Jianbao ^{[1
]}

Li, Fengbo ^{[1
]}

Li, Yanjun ^{[1
]}

机构：

[1] Tianjin Hosp, Inst Orthoped, Tianjin Tj 300050, Peoples R China

[2] Tianjin Med Univ, Grad Sch, Tianjin Tj 300070, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2015年 / 468卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Disuse osteoporosis; Naringin; Periostin; Sclerostin; beta-catenin; INDUCED OSTEOPOROSIS; EXPRESSION; WNT; STIMULATION; QUALITY; PROTEIN; LRP5;

D O I：

10.1016/j.bbrc.2015.10.152

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Periostin has an essential role in mechanotransduction in bone. Naringin, a natural flavonoid, has been evidenced for its osteoprotective role in osteoporosis, while its mechanism is far from clear. Here we show that down-regulation of periostin, and up-regulation of its downstream sclerostin and inactivation of Wnt/beta-catenin signaling were implicated in neurectomy-induced bone loss. Naringin could upregulate periostin and prevent neurectomy-induced deterioration of BMD, trabecular microstructure and bone mechanical characteristics. In conclusion, naringin could prevent progress of disuse osteoporosis in rats, which may be mediated by increased periostin expression and subsequently inhibition of sclerostin and activation of Wnt/beta-catenin signaling pathways. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：587 / 593

页数：7

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