A copper- and amine-free Sonogashira coupling reaction promoted by a ferrocene-based phosphinimine-phosphine ligand at low catalyst loading

被引：89

作者：

Arques, A ^{[1
]}

Auñon, D ^{[1
]}

Molina, P ^{[1
]}

机构：

[1] Univ Murcia, Fac Quim, Dept Quim Organ, E-30071 Murcia, Spain

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 22期

关键词：

Sonogashira reaction; copper-free; palladium; catalysis; alkynes;

D O I：

10.1016/j.tetlet.2004.03.194

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium(II) complex containing a ferrocene-based phosphinimine-phosphine ligand was applied to the amine- and copper-free Sonogashira coupling of aryl iodides and aryl bromides with terminal alkynes using 1 equiv of tetrabutyl ammonium acetate as an activator. The corresponding disubstituted alkynes were obtained in high yields and TONs using 0.1 mol% Pd-catalyst. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4337 / 4340

页数：4

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