A histone code for the DNA damage response in mammalian cells?

被引：21

作者：

Corpet, Armelle ^{[1
]}

Almouzni, Genevieve ^{[1
]}

机构：

[1] UPMC, CNRS, UMR218, Inst Curie, Paris, France

来源：

EMBO JOURNAL | 2009年 / 28卷 / 13期

关键词：

LYSINE; 56; ACETYLATION; H3; CHROMATIN;

D O I：

10.1038/emboj.2009.180

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA repair in the context of chromatin represents a challenge both in terms of accessibility to the lesion and maintenance of genome stability. Histones, the main protein component of chromatin, can be subjected to a variety of post-translational modifications (PTMs) that impact on genome function by either directly affecting nucleosome stability or providing a docking site for distinct regulatory proteins. In this issue of EMBO Journal, Tjeertes et al investigate histone PTMs with a specific involvement in the DNA damage response (DDR).

引用

收藏

页码：1828 / 1830

页数：3

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