Novel 2,2-difluorovinylzirconocene: A facile synthesis of monosubstituted gem-difluoroolefins via its cross-coupling reaction.

被引：37

作者：

Ichikawa, J ^{[1
]}

Fujiwara, M ^{[1
]}

Nawata, H ^{[1
]}

Okauchi, T ^{[1
]}

Minami, T ^{[1
]}

机构：

[1] KYUSHU INST TECHNOL,DEPT APPL CHEM,KITAKYUSHU,FUKUOKA 804,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(96)02035-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,2-Difluorovinyl p-toluenesulfonate, readily obtained from 2,2,2-trifluoroethanol, is treated with zirconocene equivalent ''Cp(2)Zr'' to generate the remarkably thermostable nonsubstituted 2,2-difluorovinylzirconocene, which in turn couples with aryliodides in the presence of palladium catalyst and zinc iodide to afford monosubstituted gem-difluoroolefins in high yields. The reaction proceeds via 2,2-difluorovinylzinc as confirmed by F-19-NMR measurement. Copyright (C) 1996 Elsevier Science Ltd.

引用

页码：8799 / 8802

页数：4

共 30 条

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