Thinking About Broadly Cross-Reactive Vaccines

被引：2

作者：

Doherty, P. C. ^{[1
,2
]}

Turner, S. J. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[2] St Jude Childrens Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2009年 / 85卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

INFLUENZA-A VIRUS; CYTOTOXIC T-LYMPHOCYTES; CELL IMMUNODOMINANCE HIERARCHY; HIV-1; VACCINE; INFECTION; IMMUNITY; MEMORY; ANTIBODY; ESCAPE; RESPONSES;

D O I：

10.1038/clpt.2009.52

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins. The CD8(+) cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?

引用

页码：665 / 668

页数：4

共 51 条

[1] Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans [J].

Assarsson, Erika ;

Bui, Huynh-Hoa ;

Sidney, John ;

Zhang, Qing ;

Glenn, Jean ;

Oseroff, Carla ;

Mbawuike, Innocent N. ;

Alexander, Jeff ;

Newman, Mark J. ;

Grey, Howard ;

Sette, Alessandro .

JOURNAL OF VIROLOGY, 2008, 82 (24) :12241-12251

[2] A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 [J].

Astronomo, Rena D. ;

Lee, Hing-Ken ;

Scanlan, Christopher N. ;

Pantophlet, Ralph ;

Huang, Cheng-Yuan ;

Wilson, Ian A. ;

Blixt, Ola ;

Dwek, Raymond A. ;

Wong, Chi-Huey ;

Burton, Dennis R. .

JOURNAL OF VIROLOGY, 2008, 82 (13) :6359-6368

[3] Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination [J].

Barouch, DH ;

Santra, S ;

Schmitz, JE ;

Kuroda, MJ ;

Fu, TM ;

Wagner, W ;

Bilska, M ;

Craiu, A ;

Zheng, XX ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Nickerson, CE ;

Trigona, WL ;

Punt, K ;

Freed, DC ;

Guan, LM ;

Dubey, S ;

Casimiro, D ;

Simon, A ;

Davies, ME ;

Chastain, M ;

Strom, TB ;

Gelman, RS ;

Montefiori, DC ;

Lewis, MG ;

Emini, EA ;

Shiver, JW ;

Letvin, NL .

SCIENCE, 2000, 290 (5491) :486-492

[4] Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes [J].

Barouch, DH ;

Kunstman, J ;

Kuroda, MJ ;

Schmitz, JE ;

Santra, S ;

Peyerl, FW ;

Krivulka, GR ;

Beaudry, K ;

Lifton, MA ;

Gorgone, DA ;

Montefiori, DC ;

Lewis, MG ;

Wolinsky, SM ;

Letvin, NL .

NATURE, 2002, 415 (6869) :335-339

[5] Structure of antibody f425-b4e8 in complex with a v3 peptide reveals a new binding mode for HIV-1 neutralization [J].

Bell, Christian H. ;

Pantophlet, Ralph ;

Schiefner, Andre ;

Cavacini, Lisa A. ;

Stanfield, Robyn L. ;

Burton, Dennis R. ;

Wilson, Ian A. .

JOURNAL OF MOLECULAR BIOLOGY, 2008, 375 (04) :969-978

[6] Fitness costs limit escape from cytotoxic T lymphocytes by influenza A viruses [J].

Berkhoff, E. G. M. ;

de Wit, E. ;

Geelhoed-Mieras, M. M. ;

Boon, A. C. M. ;

Symons, J. ;

Fouchier, R. A. M. ;

Osterhaus, A. D. M. E. ;

Rimmelzwaan, G. F. .

VACCINE, 2006, 24 (44-46) :6594-6596

[7] An amino acid substitution in the influenza A virus hemagglutinin associated with escape from recognition by human virus-specific CD4+ T-cells [J].

Berkhoff, Eufemia G. M. ;

Geelhoed-Mieras, Martina M. ;

Jonges, Marcel ;

Smith, Derek J. ;

Fouchier, Ron A. M. ;

Osterhaus, Albert D. M. E. ;

Rimmelzwaan, Guus F. .

VIRUS RESEARCH, 2007, 126 (1-2) :282-287

[8] Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial [J].

Buchbinder, Susan P. ;

Mehrotra, Devon V. ;

Duerr, Ann ;

Fitzgerald, Daniel W. ;

Mogg, Robin ;

Li, David ;

Gilbert, Peter B. ;

Lama, Javier R. ;

Marmor, Michael ;

del Rio, Carlos ;

McElrath, M. Juliana ;

Casimiro, Danilo R. ;

Gottesdiener, Keith M. ;

Chodakewitz, Jeffrey A. ;

Corey, Lawrence ;

Robertson, Michael N. .

LANCET, 2008, 372 (9653) :1881-1893

[9] Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? [J].

Cheung, CY ;

Poon, LLM ;

Lau, AS ;

Luk, W ;

Lau, YL ;

Shortridge, KF ;

Gordon, S ;

Guan, Y ;

Peiris, JSM .

LANCET, 2002, 360 (9348) :1831-1837

[10] Profound protection against respiratory challenge with a lethal H7N7 influenza A virus by increasing the magnitude of CD8+ T-cell memory [J].

Christensen, JP ;

Doherty, PC ;

Branum, KC ;

Riberdy, JM .

JOURNAL OF VIROLOGY, 2000, 74 (24) :11690-11696

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