Design, synthesis and biological evaluation of 3-amino-3-phenylpropionamide derivatives as novel μ opioid receptor ligands

被引：9

作者：

Allen, MP ^{[1
]}

Blake, JF ^{[1
]}

Bryce, DK ^{[1
]}

Haggan, ME ^{[1
]}

Liras, S ^{[1
]}

McLean, S ^{[1
]}

Segelstein, BE ^{[1
]}

机构：

[1] Pfizer Inc, Div Cent Res, Groton, CT 06340 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)00034-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

3-Amino-3-phenylpropionamide derivatives were produced as small molecule mimics of the cyclic octapeptide octreotide from readily available imine 1. The compounds exhibit high affinity for the mu opioid receptor. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：523 / 526

页数：4

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