Double-pass Mach-Zehnder fiber interferometer pH sensor

被引：16

作者：

Tou, Zhi Qiang ^{[1
]}

Chan, Chi Chiu ^{[1
]}

Hong, Jesmond ^{[1
]}

Png, Shermaine ^{[1
]}

Eddie, Khay Ming Tan ^{[2
]}

Tan, Terence Aik Huang ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Chem & Biomed Engn, Div Bioengn, Singapore 637457, Singapore

[2] EINST Technol Pte Ltd, Singapore 169203, Singapore

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2014年 / 19卷 / 04期

关键词：

fiber optic sensors; interferometers; remote sensing; pH; MELANOMA-CELLS;

D O I：

10.1117/1.JBO.19.4.047002

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A biocompatible fiber-optic pH sensor based on a unique double-pass Mach-Zehnder interferometer is proposed. pH responsive poly(2-hydroxyethyl methacrylate-co-2-(dimethylamino) ethyl methacrylate) hydrogel coating on the fiber swells/deswells in response to local pH, leading to refractive index changes that manifest as shifting of interference dips in the optical spectrum. The pH sensor is tested in spiked phosphate buffer saline and demonstrates high sensitivity of 1.71 nm/pH, pH 0.004 limit of detection with good responsiveness, repeatability, and stability. The proposed sensor has been successfully applied in monitoring the media pH in cell culture experiments to investigate the relationship between pH and cancer cell growth. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)

引用

页数：7

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