Growth inhibition by microRNAs that target the insulin receptor substrate-1

被引：17

作者：

La Rocca, Gaspare ^{[1
]}

Shi, Bin ^{[1
,2
]}

Badin, Margherita ^{[1
]}

De Angelis, Tiziana ^{[1
]}

Sepp-Lorenzino, Laura ^{[2
]}

Baserga, Renato ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Canc Biol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Merck & Co Inc, West Point, PA USA

来源：

CELL CYCLE | 2009年 / 8卷 / 14期

关键词：

microRNA; non-codingRNA; IGF-1R pathway; cellular growth; tumor suppression; GENE-EXPRESSION; I RECEPTOR; IRS-1; TRANSFORMATION; INSULIN-RECEPTOR-SUBSTRATE-1; DIFFERENTIATION; ANTIGEN; CELLS;

D O I：

10.4161/cc.8.14.9026

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have examined several microRNAs (miRs) indicated by the databases as targeting the signaling pathway of the type-1 insulin-like growth factor receptor (IGF-IR). Most of the miRs tested had multiple targets, as expected, leading to cell death. However, miR145 seemed to affect its tumor suppressor activity largely by downregulating the docking protein of the IGF-IR, the insulin receptor substrate-1 (IRS-1). These results suggest that, despite the many targets provided by the databases, in some cases a single target can be predominant in determining the end results.

引用

页码：2255 / 2259

页数：5

共 37 条

[1] Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues [J].