An overview of the serpin superfamily

被引：558

作者：

Law, Ruby H. P.

Zhang, Qingwei

McGowan, Sheena

Buckle, Ashley M.

Silverman, Gary A.

Wong, Wilson

Rosado, Carlos J.

Langendorf, Chris G.

Pike, Rob N.

Bird, Philip I.

Whisstock, James C.

机构：

[1] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic 3800, Australia

[2] Monash Univ, Victorian Bioinformat Consortium, Melbourne, Vic 3800, Australia

[3] Monash Univ, ARC Ctr Struct & Funct Microbial Genom, Melbourne, Vic 3800, Australia

[4] Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Magee Womens Res Inst,Dept Pediat, Pittsburgh, PA 15213 USA

来源：

GENOME BIOLOGY | 2006年 / 7卷 / 05期

关键词：

D O I：

10.1186/gb-2006-7-5-216

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive polymers.

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页数：11

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