Ensembl 2017

被引：408

作者：

Aken, Bronwen L. ^{[1
]}

Achuthan, Premanand ^{[1
]}

Akanni, Wasiu ^{[1
]}

Amode, M. Ridwan ^{[1
]}

Bernsdorff, Friederike ^{[1
]}

Bhai, Jyothish ^{[1
]}

Billis, Konstantinos ^{[1
]}

Carvalho-Silva, Denise ^{[1
]}

Cummins, Carla ^{[1
]}

Clapham, Peter ^{[2
]}

Gil, Laurent ^{[1
]}

Giron, Carlos Garcia ^{[1
]}

Gordon, Leo ^{[1
]}

Hourlier, Thibaut ^{[1
]}

Hunt, Sarah E. ^{[1
]}

Janacek, Sophie H. ^{[1
]}

Juettemann, Thomas ^{[1
]}

Keenan, Stephen ^{[1
]}

Laird, Matthew R. ^{[1
]}

Lavidas, Ilias ^{[1
]}

Maurel, Thomas ^{[1
]}

McLaren, William ^{[1
]}

Moore, Benjamin ^{[1
]}

Murphy, Daniel N. ^{[1
]}

Nag, Rishi ^{[1
]}

Newman, Victoria ^{[1
]}

Nuhn, Michael ^{[1
]}

Ong, Chuang Kee ^{[1
]}

Parker, Anne ^{[1
]}

Patricio, Mateus ^{[1
]}

Riat, Harpreet Singh ^{[1
]}

Sheppard, Daniel ^{[1
]}

Sparrow, Helen ^{[1
]}

Taylor, Kieron ^{[1
]}

Thormann, Anja ^{[1
]}

Vullo, Alessandro ^{[1
]}

Walts, Brandon ^{[1
]}

Wilder, Steven P. ^{[1
]}

Zadissa, Amonida ^{[1
]}

Kostadima, Myrto ^{[1
]}

Martin, Fergal J. ^{[1
]}

Muffato, Matthieu ^{[1
]}

Perry, Emily ^{[1
]}

Ruffier, Magali ^{[1
]}

Staines, Daniel M. ^{[1
]}

Trevanion, Stephen J. ^{[1
]}

Cunningham, Fiona ^{[1
]}

Yates, Andrew ^{[1
]}

Zerbino, Daniel R. ^{[1
]}

Flicek, Paul ^{[1
,2
]}

机构：

[1] European Bioinformat Inst, European Mol Biol Lab, Wellcome Genome Campus, Cambridge CB10 1SD, England

[2] Wellcome Trust Sanger Inst, Wellcome Genome Campus, Cambridge CB10 1SA, England

来源：

NUCLEIC ACIDS RESEARCH | 2017年 / 45卷 / D1期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 美国国家卫生研究院;

关键词：

GENOME ANNOTATION; DATABASE; PROJECT; REFSEQ; VISUALIZATION; SOFTWARE; CATALOG; GENCODE;

D O I：

10.1093/nar/gkw1104

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ensembl (www.ensembl.org) is a database and genome browser for enabling research on vertebrate genomes. We import, analyse, curate and integrate a diverse collection of large-scale reference data to create a more comprehensive view of genome biology than would be possible from any individual dataset. Our extensive data resources include evidence-based gene and regulatory region annotation, genome variation and gene trees. An accompanying suite of tools, infrastructure and programmatic access methods ensure uniform data analysis and distribution for all supported species. Together, these provide a comprehensive solution for large-scale and targeted genomics applications alike. Among many other developments over the past year, we have improved our resources for gene regulation and comparative genomics, and added CRISPR/Cas9 target sites. We released new browser functionality and tools, including improved filtering and prioritization of genome variation, Manhattan plot visualization for linkage disequilibrium and eQTL data, and an ontology search for phenotypes, traits and disease. We have also enhanced data discovery and access with a track hub registry and a selection of new REST end points. All Ensembl data are freely released to the scientific community and our source code is available via the open source Apache 2.0 license.

引用

页码：D635 / D642

页数：8

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