Ubiquitin linkages make a difference

被引：27

作者：

Dikic, Ivan ^{[1
,2
]}

Doetsch, Volker ^{[3
,4
]}

机构：

[1] Goethe Univ Frankfurt, Frankfurt Inst Mol Life Sci, Frankfurt, Germany

[2] Goethe Univ Frankfurt, Inst Biochem 2, Frankfurt, Germany

[3] Goethe Univ Frankfurt, Inst Biophys Chem, Frankfurt, Germany

[4] Goethe Univ Frankfurt, Ctr Biomol Magnet Resonance, Frankfurt, Germany

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 12期

关键词：

KAPPA-B ACTIVATION; CHAINS; RECOGNITION; NEMO;

D O I：

10.1038/nsmb1209-1209

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ubiquitin chains have critical roles in activating the NF-kappa B pathway and mediating immune responses. recent structural work on distinct ubiquitin chains in complexes with selective ubiquitin-binding domains provides an explanation for directionality and specificity in the NF-kappa B pathway.

引用

收藏

页码：1208 / 1210

页数：3

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