Highly stereospecific, palladium-catalyzed cross-coupling of alkenylsilanols

被引:151
作者
Denmark, SE [1 ]
Wehrli, D [1 ]
机构
[1] Univ Illinois, Dept Chem, Roger Adams Lab, Urbana, IL 61801 USA
关键词
D O I
10.1021/ol005565e
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] Alkenylsilanols bearing methyl ((E)-1 and (Z)-1) or isopropyl ((E)-2 and (Z)-2)) substituents are converted to disubstituted alkenes by a palladium(0)-catalyzed cross coupling reaction with aryl or vinyl iodides in the presence of tetrabutylammonium fluoride or hydroxide, Yields and stereoselectivities are generally high, and the reaction is compatible with a wide range of functional groups.
引用
收藏
页码:565 / 568
页数:4
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