Age-associated changes of the intestinal epithelial barrier: local and systemic implications

被引：53

作者：

Nicoletti, Claudio ^{[1
]}

机构：

[1] Inst Food Res, Gut Hlth & Food Safety Strateg Programme, Norwich NR4 7UA, Norfolk, England

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2015年 / 9卷 / 12期

基金：

英国生物技术与生命科学研究理事会;

关键词：

ageing; infection; inflammageing; intestinal permeability; intestine; microbiota; LIFE-SPAN; PERMEABILITY; THERAPY; GUT; DEPRESSION; EXPRESSION; BALANCE; DISEASE; HEALTH;

D O I：

10.1586/17474124.2015.1092872

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In the past few years, increasing evidence has suggested that alterations of the epithelial barrier of the GI tract are linked to both local and systemic disorders of various natures. However, in spite of the numerous debilitating health problems that might stem from it, very little attention has been given to how ageing affects this critical structure. Here, the most recent data on the age-associated modifications of some of the physical and immunological features of intestinal epithelial barrier are discussed along with potential strategies to restore its function and improve the quality of life of the elderly, an ever increasing demographic segment of our society.

引用

页码：1467 / 1469

页数：3

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