The myelin protein MAL affects peripheral nerve myelination: a new player influencing p75 neurotrophin receptor expression

被引：16

作者：

Buser, A. M. ^{[1
]}

Schmid, D. ^{[1
]}

Kern, F. ^{[1
]}

Erne, B. ^{[1
]}

Lazzati, T. ^{[1
]}

Schaeren-Wiemers, N. ^{[1
]}

机构：

[1] Univ Basel Hosp, Dept Biomed & Neurol, Pharmactr 7007, CH-4056 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

axon-glia interaction; mouse; p75 neurotrophin receptor; peripheral myelination; Schwann cell development; trafficking; sorting; RAFT-ASSOCIATED PROTEIN; DARBY CANINE KIDNEY; LIPID RAFTS; APICAL TRANSPORT; CELLS; OLIGODENDROCYTES; MICRODOMAINS; P75(NTR); GENE; NEUREGULIN-1;

D O I：

10.1111/j.1460-9568.2009.06785.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The myelin and lymphocyte protein (MAL) is a raft-associated membrane protein predominantly expressed by oligodendrocytes and Schwann cells. Here we show that MAL regulates myelination in the peripheral nervous system. In mice overexpressing MAL, myelination was retarded and fibers were hypomyelinated, whereas myelination in MAL knockout mice was accelerated. This was not due to impaired Schwann cell proliferation, differentiation or axonal sorting. We found that the expression level of p75 neurotrophin receptor mRNA and protein was strongly reduced in developing sciatic nerves in MAL-overexpressing mice. This reduction is well correlated with the observed alterations in myelination initiation, speed of myelination and alterations in Remak bundle development. Our results suggest a functional role for MAL in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.

引用

页码：2276 / 2290

页数：15

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