Molecular characterization of feline interleukin 16: Chemotactic activity and effect on feline immunodeficiency virus infection and/or replication

被引：5

作者：

Leutenegger, CM ^{[1
]}

Huder, JB

Mislin, CN

Lahrtz, F

Hofmann-Lehmann, R

Pedersen, NC

Lutz, H

机构：

[1] Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA

[2] Univ Zurich, Clin Lab, Dept Vet Internal Med, CH-8057 Zurich, Switzerland

[3] Univ Zurich Hosp, Dept Internal Med, CH-8091 Zurich, Switzerland

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2000年 / 16卷 / 06期

关键词：

D O I：

10.1089/088922200308981

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin 16 (IL-16) has been shown to diminish HIV and SIV replication through inhibition of HIV and SN mRNA transcription. To evaluate its role in the FIV cat model, we cloned and expressed feline LL-16 and determined its ability to induce chemotaxis as well as to inhibit FN replication in cultured PBMCs. Sequence comparison of rfIL-16 with human, African green monkey, rhesus macaque, and mouse IL-16 showed 84.2, 84.5, 84.4, and 79.4% identity at the nucleotide sequence level and 93, 91.5, 90.7, and 87.2% identity at the amino acid sequence level? respectively. Biocharacterization of rfIL-16 revealed potent induction of chemotaxis (p < 0.05), In addition, p24 production from feline PBMCs infected with FIV Zurich 2 in vitro was decreased up to 87% (p < 0.05), These data demonstrate biologic and antiviral functionality of rfIL-16.

引用

页码：569 / 575

页数：7

共 30 条

[11]

Laberge S, 1996, J IMMUNOL, V156, P310

[12]

LABERGE S, 1995, J IMMUNOL, V155, P2902

[13] Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: Biologic activity and effect on simian immunodeficiency virus infection and/or replication [J].

Lee, ME ;

Adams, JW ;

Villinger, F ;

Brar, SS ;

Meadows, M ;

Bucur, SZ ;

Lackey, DA ;

Brice, GT ;

Cruikshank, WW ;

Ansari, AA ;

Hillyer, CD .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (15) :1323-1328

[14] Molecular cloning and expression of feline interleukin-16 [J].

Leutenegger, CM ;

Huder, JB ;

Hofmann-Lehmann, R ;

Lutz, H .

DNA SEQUENCE, 1998, 9 (01) :59-63

[15] Partial protection by vaccination with recombinant feline immunodeficiency virus surface glycoproteins [J].

Leutenegger, CM ;

Hofmann-Lehmann, R ;

Holznagel, E ;

Cuisinier, AM ;

Wolfensberger, C ;

Duquesne, V ;

Cronier, J ;

Allenspach, K ;

Aubert, A ;

Ossent, P ;

Lutz, H .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1998, 14 (03) :275-283

[16] Controlling HIV pathogenesis: The role of the noncytotoxic anti-HIV response of CD8(+) T cells [J].

Levy, JA ;

Mackewicz, CE ;

Barker, E .

IMMUNOLOGY TODAY, 1996, 17 (05) :217-224

[17] Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation [J].

Liu, Y ;

Cruikshank, WW ;

O'Loughlin, T ;

O'Reilly, P ;

Center, DM ;

Kornfeld, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (33) :23387-23395

[18]

Maciaszek JW, 1997, J IMMUNOL, V158, P5

[19] Role of IL-16 in HIV replication [J].

Mackewicz, CE ;

Levy, JA ;

Cruikshank, WW ;

Kornfeld, H ;

Center, DM .

NATURE, 1996, 383 (6600) :488-489

[20] CD8(+) T-CELLS SUPPRESS HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION BY INHIBITING VIRAL TRANSCRIPTION [J].

MACKEWICZ, CE ;

BLACKBOURN, DJ ;

LEVY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) :2308-2312

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