Multidrug resistance in haematological malignancies

被引：56

作者：

Sonneveld, P ^{[1
]}

机构：

[1] Univ Hosp Rotterdam Dijkzigt, Dept Hematol, NL-3015 GD Rotterdam, Netherlands

来源：

JOURNAL OF INTERNAL MEDICINE | 2000年 / 247卷 / 05期

关键词：

acute myeloid leukaemia; MDR; MRP; multiple myeloma; multidrug resistance; P-glycoprotein; PSC; 833;

D O I：

10.1046/j.1365-2796.2000.00689.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of refractory disease in acute myeloid or lymphoblastic leukaemias (AML, ALL) and multiple myeloma (MM) is frequently associated with the expression of one or several multidrug resistance (MDR) genes. MDR1, MRP1 and LRP have been identified as important adverse prognostic factors in AML, T-ALL and MM. Recently, it has become possible to reverse clinical multidrug resistance by blocking P-glycoprotein-mediated drug efflux. The potential relevance of these reversal agents of MDR and potential new approaches to treat refractory disease are discussed.

引用

页码：521 / 534

页数：14

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