Regulation of ovulation rate in mammals: contribution of sheep genetic models

被引：169

作者：

Fabre, Stephane ^{[1
]}

Pierre, Alice

Mulsant, Philippe

Bodin, Loys

Di Pasquale, Elisa

Persani, Luca

Monget, Philippe

Monniaux, Danielle

机构：

[1] Univ Tours Haras Nationaux, CNRS, UMR 6175, INRA, F-37380 Nouzilly, France

[2] INRA, Lab Genet Cellulaire, F-31326 Castanet Tolosan, France

[3] INRA, Stn Ameliorat Genet Anim, F-31326 Castanet Tolosan, France

[4] Univ Milan, Inst Endocrine Sci, Ist Auxol Italiano, IRCCS, I-20095 Cusano Milanino, MI, Italy

来源：

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY | 2006年 / 4卷 / 1期

关键词：

D O I：

10.1186/1477-7827-4-20

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ovarian folliculogenesis in mammals from the constitution of primordial follicles up to ovulation is a reasonably well understood mechanism. Nevertheless, underlying mechanisms that determine the number of ovulating follicles were enigmatic until the identification of the fecundity genes affecting ovulation rate in sheep, bone morphogenetic protein-15 (BMP-15), growth and differentiation factor-9 (GDF-9) and BMP receptor-1B (BMPR-1B). In this review, we focus on the use of these sheep genetic models for understanding the role of the BMP system as an intra-ovarian regulator of follicular growth and maturation, and finally, ovulation rate.

引用

页数：12

共 76 条

[31] Comparison of recombinant growth differentiation factor-9 and oocyte regulation of KIT ligand messenger ribonucleic acid expression in mouse ovarian follicles [J].

Joyce, IM ;

Clark, AT ;

Pendola, FL ;

Eppig, JJ .

BIOLOGY OF REPRODUCTION, 2000, 63 (06) :1669-1675

[32] Growth differentiation factor 9 and bone morphogenetic protein 15 are essential for ovarian follicular development in sheep [J].

Juengel, JL ;

Hudson, NL ;

Heath, DA ;

Smith, P ;

Reader, KL ;

Lawrence, SB ;

O'Connell, AR ;

Laitinen, MPE ;

Cranfield, M ;

Groome, NP ;

Ritvos, O ;

McNatty, KP .

BIOLOGY OF REPRODUCTION, 2002, 67 (06) :1777-1789

[33] Effects of immunization against bone morphogenetic protein 15 and growth differentiation factor 9 on ovulation rate, fertilization, and pregnancy in ewes [J].

Juengel, JL ;

Hudson, NL ;

Whiting, L ;

McNatty, KP .

BIOLOGY OF REPRODUCTION, 2004, 70 (03) :557-561

[34]

LECERF F, 2002, P 7 WORLD C GEN APPL, V30, P753

[35] Effect of bone morphogenetic protein-7 on folliculogenesis and ovulation in the rat [J].

Lee, WS ;

Otsuka, F ;

Moore, RK ;

Shimasaki, S .

BIOLOGY OF REPRODUCTION, 2001, 65 (04) :994-999

[36] Effect of intracellular interactions on the processing and secretion of bone morphogenetic protean-15 (BMP-15) and growth and differentiation factor-9 - Implication of the aberrant ovarian phentype of BMP-15 mutant sheep [J].

Liao, WX ;

Moore, RK ;

Otsuka, F ;

Shimasaki, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (06) :3713-3719

[37] Functional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9 [J].

Liao, WX ;

Moore, RK ;

Shimasaki, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (17) :17391-17396

[38] Expression profiles and chromosomal localization of genes controlling meiosis and follicular development in the sheep ovary [J].

Mandon-Pépin, B ;

Oustry-Vaiman, A ;

Vigier, B ;

Piumi, F ;

Cribiu, E ;

Cotinot, C .

BIOLOGY OF REPRODUCTION, 2003, 68 (03) :985-995

[39] Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5 [J].

Mazerbourg, S ;

Klein, C ;

Roh, J ;

Kaivo-Oja, N ;

Mottershead, DG ;

Korchynskyi, O ;

Ritvos, O ;

Hsueh, AJW .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (03) :653-665

[40] Physiological effects of major genes affecting ovulation rate in sheep [J].

McNatty, KP ;

Galloway, SM ;

Wilson, T ;

Smith, P ;

Hudson, NL ;

O'Connell, A ;

Bibby, AH ;

Heath, DA ;

Davis, GH ;

Hanrahan, JP ;

Juengel, JL .

GENETICS SELECTION EVOLUTION, 2005, 37 :S25-S38

← 1 2 3 4 5 6 7 8 →