The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins

被引：63

作者：

Gu, WL

Wevers, A

Schröder, H

Grzeschik, KH

Derst, C

Brodtkorb, E

de Vos, R

Steinlein, OK

机构：

[1] Univ Hosp Bonn, Inst Human Genet, D-53111 Bonn, Germany

[2] Univ Cologne, Inst Anat 2, D-50931 Cologne, Germany

[3] Univ Marburg, Dept Human Genet, D-35037 Marburg, Germany

[4] Univ Freiburg, Inst Physiol 2, D-79104 Freiburg, Germany

[5] Univ Trondheim Hosp, Dept Neurol, N-7006 Trondheim, Norway

[6] Lab Pathol Oost Nederland, NL-7512 AD Enschede, Netherlands

来源：

FEBS LETTERS | 2002年 / 519卷 / 1-3期

关键词：

epilepsy; glioma; chromosomal localization; expression profile; gene family;

D O I：

10.1016/S0014-5793(02)02713-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently mutations in the LGI1 (leucine-rich, gliomainactivated 1) gene have been found in human temporal lobe epilepsy. We have now identified three formerly unknown LGI-like genes. Hydropathy plots and pattern analysis showed that LGI genes encode proteins with large extra- and intracellular domains connected by a single transmembrane region. Sequence analysis demonstrated that LGI1, LGI2, LGI3, and LGI4 form a distinct subfamily when compared to other leucine-rich repeat-containing proteins. In silico mapping and radiation hybrid experiments assigned LGI2, LGI3, and LGI4 to different chromosomal regions (4p15.2, 8p21.3, 19q13.11), some of which have been implicated in epileptogenesis and/or tumorigenesis. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：71 / 76

页数：6

共 18 条

[11]

Shao JY, 2001, ANTICANCER RES, V21, P3021

[12]

Shivapurkar N, 1999, CLIN CANCER RES, V5, P17

[13] Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma [J].

Shivapurkar, N ;

Maitra, A ;

Milchgrub, S ;

Gazdar, AF .

HUMAN PATHOLOGY, 2001, 32 (02) :169-177

[14]

Smith JS, 2000, GENE CHROMOSOME CANC, V29, P16, DOI 10.1002/1098-2264(2000)9999:9999<::AID-GCC1007>3.3.CO

[15]

2-9

[16] Genes and mutations in idiopathic epilepsy [J].

Steinlein, OK .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 106 (02) :139-145

[17] A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy [J].

Stogmann, E ;

Zimprich, A ;

Baumgartner, C ;

Aull-Watschinger, S ;

Höllt, V ;

Zimprich, F .

ANNALS OF NEUROLOGY, 2002, 51 (02) :260-263

[18] A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region [J].

Wright, TJ ;

Ricke, DO ;

Denison, K ;

Abmayr, S ;

Cotter, PD ;

Hirschhorn, K ;

Keinanen, M ;

McDonaldMcGinn, D ;

Somer, M ;

Spinner, N ;

YangFeng, T ;

Zackai, E ;

Altherr, MR .

HUMAN MOLECULAR GENETICS, 1997, 6 (02) :317-324

← 1 2 →