Relationship between stiffness and force in single molecule pulling experiments

被引：21

作者：

Liu, YZ ^{[1
]}

Leuba, SH ^{[1
]}

Lindsay, SM ^{[1
]}

机构：

[1] Arizona State Univ, Dept Phys & Astron, Tempe, AZ 85287 USA

来源：

LANGMUIR | 1999年 / 15卷 / 24期

关键词：

D O I：

10.1021/la990267f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Single molecule pulling experiment was performed wherein the tip is oscillated at the same time as the molecule is pulled. The force and stiffness data were found to be in excellent agreement in regions of conservative behavior suggesting that elastic behavior dominates this region of the pulling curve at the frequency used for measurement. This shows how simultaneous acquisition of static and oscillatory data serves as a check of nondissipative, nondispersive behavior. Portions of the curve must correspond to an elastic distortion of the chromatin. In addition, more complex behavior could be studied by recording both the amplitude and phase of the cantilever displacement over a wide range of frequencies.

引用

页码：8547 / 8548

页数：2

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