The logic of TGFβ signaling

被引：635

作者：

Massague, Joan ^{[1
]}

Gomis, Roger R. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Canc Biol & Genet Program, New York, NY 10021 USA

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

TGFP; Smad transcription factor; receptor serine/threonine kinase; cell cycle; cyclin-dependent kinase; cytostasis; tumor suppressor; cancer; metastasis;

D O I：

10.1016/j.febslet.2006.04.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The identification of the TGF beta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

收藏

页码：2811 / 2820

页数：10

相关论文

共 108 条

[81] Integration of Smad and Forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation [J].

Seoane, J ;

Le, HV ;

Shen, LJ ;

Anderson, SA ;

Massagué, J .

CELL, 2004, 117 (02) :211-223

[82] Myc suppression of the p21Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage [J].

Seoane, J ;

Le, HV ;

Massagué, J .

NATURE, 2002, 419 (6908) :729-734

[83] TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b [J].

Seoane, J ;

Pouponnot, C ;

Staller, P ;

Schader, M ;

Eilers, M ;

Massagué, J .

NATURE CELL BIOLOGY, 2001, 3 (04) :400-408

[84] Crystal structure of a Smad MH1 domain bound to DNA:: Insights on DNA binding in TGF-β signaling [J].

Shi, YG ;

Wang, YF ;

Jayaraman, L ;

Yang, HJ ;

Massagué, J ;

Pavletich, NP .

CELL, 1998, 94 (05) :585-594

[85] Mechanisms of TGF-β signaling from cell membrane to the nucleus [J].

Shi, YG ;

Massagué, J .

CELL, 2003, 113 (06) :685-700

[86] Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer [J].

Siegel, PM ;

Massagué, J .

NATURE REVIEWS CANCER, 2003, 3 (11) :807-820

[87] Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis [J].

Siegel, PM ;

Shu, WP ;

Cardiff, RD ;

Muller, WJ ;

Massagué, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (14) :8430-8435

[88] The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo [J].

Sirard, C ;

de la Pompa, JL ;

Elia, A ;

Itie, A ;

Mirtsos, C ;

Cheung, A ;

Hahn, S ;

Wakeham, A ;

Schwartz, L ;

Kern, SE ;

Rossant, J ;

Mak, TW .

GENES & DEVELOPMENT, 1998, 12 (01) :107-119

[89] Repression of p15INK4b expression by Myc through association with Miz-1 [J].

Staller, P ;

Peukert, K ;

Kiermaier, A ;

Seoane, J ;

Lukas, J ;

Karsunky, H ;

Möröy, T ;

Bartek, J ;

Massagué, J ;

Hänel, F ;

Eilers, M .

NATURE CELL BIOLOGY, 2001, 3 (04) :392-399

[90] Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype [J].

Subramanian, G ;

Schwarz, RE ;

Higgins, L ;

McEnroe, G ;

Chakravarty, S ;

Dugar, S ;

Reiss, M .

CANCER RESEARCH, 2004, 64 (15) :5200-5211

← 2 3 4 5 6 7 8 9 10 11 →