Optical fiber SPR biosensor with sandwich assay for the detection of prostate specific antigen

被引：89

作者：

Jang, Hyun Soo ^{[1
]}

Park, Kwang No ^{[1
]}

Kang, Chang Duk ^{[2
]}

Kim, Jun Pyo ^{[2
]}

Sim, Sang Jun ^{[2
]}

Lee, Kyung Shik ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Informat & Commun Engn, Suwon 440746, South Korea

[2] Sungkyunkwan Univ, Dept Chem Engn, Suwon 440746, South Korea

来源：

OPTICS COMMUNICATIONS | 2009年 / 282卷 / 14期

关键词：

Optical fiber sensor; Surface plasmon resonance (SPR); Biosensor; Detection; SURFACE-PLASMON RESONANCE; MODE;

D O I：

10.1016/j.optcom.2009.03.078

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We present a new, sensitive, few mode fiber (FMF) surface plasmon resonance (SPR) biosensor with a sandwich assay for the detection of PSA. The side-polished FMF biosensor does not need a polarizer and a thin high-index overlayer. The optical sensitivity of the SPR sensor was determined as 2.5 x 10(-6) RIU. In the SPR PSA sensor, the SPR signals were amplified by a factor of 6 in average over no secondary antibody, using the sandwich assay. The proposed FMF SPR biosensor has great potential for real-time analysis of immune reaction between biomolecules and the advantages of high-sensitivity and label-free detection. (c) 2009 Elsevier B.V. All rights reserved.

引用

页码：2827 / 2830

页数：4

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