Microbiota and neurodevelopmental windows: implications for brain disorders

被引：808

作者：

Borre, Yuliya E. ^{[1
]}

O'Keeffe, Gerard W. ^{[2
,3
]}

Clarke, Gerard ^{[1
,4
]}

Stanton, Catherine ^{[4
,5
]}

Dinan, Timothy G. ^{[1
,4
]}

Cryan, John F. ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Lab NeuroGastroenterol, Cork, Ireland

[2] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

[3] Cork Univ Matern Hosp, INFANT, Irish Ctr Fetal & Neonatal Translat Res, Cork, Ireland

[4] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland

[5] Teagasc Food Res Ctr, Cork, Ireland

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 09期

关键词：

brain-gut axis; stress; neurogastroenterology; microbiome; brain disorders; autism; AUTISM SPECTRUM DISORDERS; HUMAN INTESTINAL MICROBIOTA; INFLAMMATORY-BOWEL-DISEASE; HUMAN PREFRONTAL CORTEX; CENTRAL-NERVOUS-SYSTEM; ANXIETY-LIKE BEHAVIOR; GUT MICROBIOTA; LEAKY GUT; CAMPYLOBACTER-JEJUNI; VAGAL-AFFERENTS;

D O I：

10.1016/j.molmed.2014.05.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gut microbiota is essential to human health, playing a major role in the bidirectional communication between the gastrointestinal tract and the central nervous system. The microbiota undergoes a vigorous process of development throughout the lifespan and establishes its symbiotic rapport with the host early in life. Early life perturbations of the developing gut microbiota can impact neurodevelopment and potentially lead to adverse mental health outcomes later in life. This review compares the parallel early development of the intestinal microbiota and the nervous system. The concept of parallel and interacting microbial-neural critical windows opens new avenues for developing novel microbiota-modulating based therapeutic interventions in early life to combat neurodevelopmental deficits and brain disorders.

引用

页码：509 / 518

页数：10

共 116 条

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