Thermogelling biodegradable copolymer aqueous solutions for injectable protein delivery and tissue engineering

被引:121
作者
Jeong, B
Lee, KM
Gutowska, A
An, YHH
机构
[1] Pacific NW Natl Lab, Richland, WA 99352 USA
[2] Ewha Womans Univ, Dept Chem, Seoul 120750, South Korea
[3] Med Univ S Carolina, Dept Orthoped Surg, Charleston, SC 29425 USA
关键词
D O I
10.1021/bm025536m
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This paper reports on the thermogelling, biodegradable polymer formulations based on poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers for in vivo biomedical applications using animal models. The description includes diabetic control by sustained insulin delivery and cartilage repair by chondrocyte cell delivery. With one injection of the poly(DL-lactic acid-co-glycolic acid)/(poly(ethylene glycol) graft copolymers insulin formulation, the blood glucose level could be controlled from 5 to 16 days in diabetic rats by varying the polymer composition. The cartilage defect was notably repaired using chondrocyte suspension in the thermogelling PLGA-g-PEG compared with a control. This report shows that thermogelling biodegradable PLGA/PEG graft copolymer system can be a promising platform for protein and cell-based therapy.
引用
收藏
页码:865 / 868
页数:4
相关论文
共 22 条
[1]  
Ahn Y., 2001, US patent, Patent No. [US 6103528, 6103528]
[2]   Synthesis and characterization of triblock copolymers of methoxy poly(ethylene glycol) and poly(propylene fumarate) [J].
Behravesh, E ;
Shung, AK ;
Jo, S ;
Mikos, AG .
BIOMACROMOLECULES, 2002, 3 (01) :153-158
[3]   Novel family of thermogelling materials via C-C bonding between poly(acrylic acid) and poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) [J].
Bromberg, L .
JOURNAL OF PHYSICAL CHEMISTRY B, 1998, 102 (11) :1956-1963
[4]   Novel injectable neutral solutions of chitosan form biodegradable gels in situ [J].
Chenite, A ;
Chaput, C ;
Wang, D ;
Combes, C ;
Buschmann, MD ;
Hoemann, CD ;
Leroux, JC ;
Atkinson, BL ;
Binette, F ;
Selmani, A .
BIOMATERIALS, 2000, 21 (21) :2155-2161
[5]  
CHUNG YM, 2002, BIOMACROMOLECULES, V3
[6]  
Gran H. H., 1902, Norg. Fish Invest, V2, P1
[7]   Injectable gels for tissue engineering [J].
Gutowska, A ;
Jeong, B ;
Jasionowski, M .
ANATOMICAL RECORD, 2001, 263 (04) :342-349
[8]   Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions [J].
Jeong, B ;
Bae, YH ;
Kim, SW .
MACROMOLECULES, 1999, 32 (21) :7064-7069
[9]   Thermosensitive sol-gel reversible hydrogels [J].
Jeong, B ;
Kim, SW ;
Bae, YH .
ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (01) :37-51
[10]   Biodegradable thermoreversible gelling PLGA-g-PEG copolymers [J].
Jeong, B ;
Wang, LQ ;
Gutowska, A .
CHEMICAL COMMUNICATIONS, 2001, (16) :1516-1517