In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin

被引：13

作者：

Alou, L ^{[1
]}

Cafini, F ^{[1
]}

Sevillano, D ^{[1
]}

Unzueta, I ^{[1
]}

Prieto, J ^{[1
]}

机构：

[1] Fac Med, Dept Microbiol 1, Madrid 28040, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 23卷 / 05期

关键词：

prophylaxis; catheters; vascular-graft infection;

D O I：

10.1016/j.ijantimicag.2003.09.030

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mupirocin and amoxicillin-clavulanate were synergistic against 9 of 49 (18%) strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (CNS). A pattern of enhanced killing was also found using time-kill studies. Time-kill assays were more discriminatory than chequerboard titration assays in demonstrating synergy. These results suggest that combinations of amoxicillin-clavulanate and mupirocin may have therapeutic benefits in prophylaxis against staphylococcal infections. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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收藏

页码：513 / 516

页数：4

相关论文

共 18 条

[1] Activities of levofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with amikacin, against acinetobacters as determined by checkerboard and time-kill studies [J].

Bajaksouzian, S ;

Visalli, MA ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1073-1076

[2] Antipneumococcal activities of cefpirome and cefotaxime, alone and in combination with vancomycin and teicoplanin, determined by checkerboard and time-kill methods [J].

Bajaksouzian, S ;

Visalli, MA ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) :1973-1976

[3] Comparison of methodologies for synergism testing of drug combinations against resistant strains of Pseudomonas aeruginosa [J].

Cappelletty, DM ;

Rybak, MJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (03) :677-683

[4] INVITRO ACTIVITY OF MUPIROCIN (PSEUDOMONIC ACID) AGAINST CLINICAL ISOLATES OF STAPHYLOCOCCUS-AUREUS [J].

CASEWELL, MW ;

HILL, RLR .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1985, 15 (05) :523-531

[5] Combinations of vancomycin and β-lactams are synergistic against staphylococci with reduced susceptibilities to vancomycin [J].

Climo, MW ;

Patron, RL ;

Archer, GL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (07) :1747-1753

[6] THE PROPHYLACTIC ACTIVITY OF AMOXYCILLIN CLAVULANATE AND CEFOXITIN IN VASCULAR-SURGERY - A RANDOMIZED CLINICAL-STUDY [J].

DIETERICH, HJ ;

GROH, J ;

BEHRINGER, K ;

LAUTERJUNG, L ;

MARTIN, E .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1989, 24 :209-211

[7] Vancomycin and oxacillin synergy for methicillin-resistant staphylococci [J].

Domaracki, BE ;

Evans, AM ;

Venezia, RA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (05) :1394-1396

[8]

Eliopolous GM., 1996, Antibiotics in laboratory medicine, P330

[9] Interpretive criteria for testing susceptibility of staphylococci to mupirocin [J].

Finlay, JE ;

Miller, LA ;

Poupard, JA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1137-1139

[10] Prophylaxis against Staphylococcus aureus vascular graft infection with mupirocin-soaked, collagen-sealed dacron [J].

Ghiselli, R ;

Giacometti, A ;

Goffi, L ;

Cirioni, O ;

Mocchegiani, F ;

Orlando, F ;

Paggi, AM ;

Petrelli, E ;

Scalise, G ;

Saba, V .

JOURNAL OF SURGICAL RESEARCH, 2001, 99 (02) :316-320