In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin

被引:13
作者
Alou, L [1 ]
Cafini, F [1 ]
Sevillano, D [1 ]
Unzueta, I [1 ]
Prieto, J [1 ]
机构
[1] Fac Med, Dept Microbiol 1, Madrid 28040, Spain
关键词
prophylaxis; catheters; vascular-graft infection;
D O I
10.1016/j.ijantimicag.2003.09.030
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Mupirocin and amoxicillin-clavulanate were synergistic against 9 of 49 (18%) strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (CNS). A pattern of enhanced killing was also found using time-kill studies. Time-kill assays were more discriminatory than chequerboard titration assays in demonstrating synergy. These results suggest that combinations of amoxicillin-clavulanate and mupirocin may have therapeutic benefits in prophylaxis against staphylococcal infections. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
引用
收藏
页码:513 / 516
页数:4
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