Peripheral arterial disease and Virchow's triad

被引：33

作者：

Bennett, Philip C. ^{[2
]}

Silverman, Stanley H. ^{[2
]}

Gill, Paramjit S. ^{[3
]}

Lip, Gregory Y. H. ^{[1
]}

机构：

[1] City Hosp Birmingham, Univ Dept Med, Haemostasis Thrombosis &Vasc Biol Unit, Birmingham B18 7QH, W Midlands, England

[2] City Hosp Birmingham, Dept Vasc Surg, Birmingham B18 7QH, W Midlands, England

[3] Univ Birmingham, Dept Primary Care & Gen Practice, Birmingham, W Midlands, England

来源：

THROMBOSIS AND HAEMOSTASIS | 2009年 / 101卷 / 06期

关键词：

Arterial thrombosis; clinical studies; risk factors; INTIMA-MEDIA THICKNESS; VON-WILLEBRAND-FACTOR; ANKLE-BRACHIAL INDEX; C-REACTIVE PROTEIN; WALL SHEAR-STRESS; CIRCULATING ENDOTHELIAL-CELLS; CARDIOVASCULAR RISK-FACTORS; FIBRIN D-DIMER; INTERCELLULAR-ADHESION MOLECULE-1; PLASMINOGEN-ACTIVATOR INHIBITOR-1;

D O I：

10.1160/TH08-08-0518

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Peripheral arterial disease (PAD) is an important global health-care problem associated with considerable morbidity and mortality. This disease is an important manifestation of atherosclerosis and the pathophysiological processes involved in its development, progression and complications are atherothrombosis and thromboembolism. Over 150 years ago, Virchow described a triad of abnormalities (abnormal blood flow, abnormal vessel wall and abnormal blood constituents) associated with thrombus formation (thrombogenesis). An improvement in biochemical techniques has allowed quantification of various components of Virchow's triad, and as a consequence, there has been increasing interest in the measurement of such biomarkers in understanding the development and progression of PAD, as well as its symptomatic complications. This review discusses quantifiable components of Virchow's triad that have been associated with PAD and their clinical utility as risk factors for PAD.

引用

页码：1032 / 1040

页数：9

共 164 条

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