Halorhodopsin: light-driven ion pumping made simple?

被引：84

作者：

Essen, LO ^{[1
]}

机构：

[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2002年 / 12卷 / 04期

关键词：

D O I：

10.1016/S0959-440X(02)00356-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Halorhodopsin, a light-driven halide pump, is the second archaeal rhodopsin involved in ion pumping to be studied at high resolution by X-ray crystallography, Like its cousin bacteriorhodopsin, halorhodopsin couples vectorial ion transport to the isomerisation state of a covalently linked retinal. Given the similarity and interconvertability of these two ion pumps, a unified mechanism for ion translocation by archaeal rhodopsins is now emerging.

引用

收藏

页码：516 / 522

页数：7

相关论文

共 52 条

[11] High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle [J].

Edman, K ;

Nollert, P ;

Royant, A ;

Belrhali, H ;

Pebay-Peyroula, E ;

Hajdu, J ;

Neutze, R ;

Landau, EM .

NATURE, 1999, 401 (6755) :822-826

[12] Lipid patches in membrane protein oligomers: Crystal structure of the bacteriorhodopsin-lipid complex [J].

Essen, LO ;

Siegert, R ;

Lehmann, WD ;

Oesterhelt, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11673-11678

[13] Chromophore-anion interactions in halorhodopsin from Natronobacterium pharaonis probed by time-resolved resonance Raman spectroscopy [J].

Gerscher, S ;

Mylrajan, M ;

Hildebrandt, P ;

Baron, MH ;

Muller, R ;

Engelhard, M .

BIOCHEMISTRY, 1997, 36 (36) :11012-11020

[14] Static and time-resolved step-scan Fourier transform infrared investigations of the photoreaction of halorhodopsin from Natronobacterium pharaonis:: Consequences for models of the anion translocation mechanism [J].

Hackmann, C ;

Guijarro, J ;

Chizhov, I ;

Engelhard, M ;

Rödig, C ;

Siebert, F .

BIOPHYSICAL JOURNAL, 2001, 81 (01) :394-406

[15] General concept fur ion translocation by halobacterial retinal proteins: The isomerization/switch/transfer (IST) model [J].

Haupts, U ;

Tittor, J ;

Bamberg, E ;

Oesterhelt, D .

BIOCHEMISTRY, 1997, 36 (01) :2-7

[16] PROJECTION STRUCTURE OF HALORHODOPSIN FROM HALOBACTERIUM-HALOBIUM AT 6-ANGSTROM RESOLUTION OBTAINED BY ELECTRON CRYOMICROSCOPY [J].

HAVELKA, WA ;

HENDERSON, R ;

HEYMANN, JAW ;

OESTERHELT, D .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 234 (03) :837-846

[17] 3-DIMENSIONAL STRUCTURE OF HALORHODOPSIN AT 7-ANGSTROM RESOLUTION [J].

HAVELKA, WA ;

HENDERSON, R ;

OESTERHELT, D .

JOURNAL OF MOLECULAR BIOLOGY, 1995, 247 (04) :726-738

[18] Halide dependence of the halorhodopsin photocycle as measured by time-resolved infrared spectra [J].

Hutson, MS ;

Shilov, SV ;

Krebs, R ;

Braiman, MS .

BIOPHYSICAL JOURNAL, 2001, 80 (03) :1452-1465

[19] Structure of the light-driven chloride pump halorhodopsin at 1.8 Å resolution [J].

Kolbe, M ;

Besir, H ;

Essen, LO ;

Oesterhelt, D .

SCIENCE, 2000, 288 (5470) :1390-1396

[20] Characterization of the proton-transporting photocycle of pharaonis halorhodopsin [J].

Kulcsár, A ;

Groma, GI ;

Lanyi, JK ;

Váró, G .

BIOPHYSICAL JOURNAL, 2000, 79 (05) :2705-2713

← 1 2 3 4 5 6 →