Halorhodopsin: light-driven ion pumping made simple?

被引:84
作者
Essen, LO [1 ]
机构
[1] Univ Marburg, Dept Chem, D-35032 Marburg, Germany
关键词
D O I
10.1016/S0959-440X(02)00356-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Halorhodopsin, a light-driven halide pump, is the second archaeal rhodopsin involved in ion pumping to be studied at high resolution by X-ray crystallography, Like its cousin bacteriorhodopsin, halorhodopsin couples vectorial ion transport to the isomerisation state of a covalently linked retinal. Given the similarity and interconvertability of these two ion pumps, a unified mechanism for ion translocation by archaeal rhodopsins is now emerging.
引用
收藏
页码:516 / 522
页数:7
相关论文
共 52 条
[21]   The three-dimensional structure of halorhodopsin to 5 Å by electron crystallography:: A new unbending procedure for two-dimensional crystals by using a global reference structure [J].
Kunji, ERS ;
von Gronau, S ;
Oesterhelt, D ;
Henderson, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (09) :4637-4642
[22]   Characterization of the azide-dependent bacteriorhodopsin-like photocycle of salinarum halorhodopsin [J].
Lakatos, M ;
Groma, GI ;
Ganea, C ;
Lanyi, JK ;
Váró, G .
BIOPHYSICAL JOURNAL, 2002, 82 (04) :1687-1695
[23]   Lipidic cubic phases: A novel concept for the crystallization of membrane proteins [J].
Landau, EM ;
Rosenbusch, JP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14532-14535
[25]   Bacteriorhodopsin [J].
Lanyi, JK ;
Luecke, H .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (04) :415-419
[26]  
Losi A, 2001, PHOTOCHEM PHOTOBIOL, V74, P495, DOI 10.1562/0031-8655(2001)074<0495:TOTESI>2.0.CO
[27]  
2
[28]   Charge motions during the photocycle of pharaonis halorhodopsin [J].
Ludmann, K ;
Ibron, G ;
Lanyi, JK ;
Váró, G .
BIOPHYSICAL JOURNAL, 2000, 78 (02) :959-966
[29]   Atomic resolution structures of bacteriorhodopsin photocycle intermediates: the role of discrete water molecules in the function of this light-driven ion pump [J].
Luecke, H .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2000, 1460 (01) :133-156
[30]   Structural changes in bacteriorhodopsin during ion transport at 2 Angstrom resolution [J].
Luecke, H ;
Schobert, B ;
Richter, HT ;
Cartailler, JP ;
Lanyi, JK .
SCIENCE, 1999, 286 (5438) :255-260