The Automation of Science

被引：382

作者：

King, Ross D. ^{[1
]}

Rowland, Jem ^{[1
]}

Oliver, Stephen G. ^{[2
]}

Young, Michael ^{[3
]}

Aubrey, Wayne ^{[1
]}

Byrne, Emma ^{[1
]}

Liakata, Maria ^{[1
]}

Markham, Magdalena ^{[1
]}

Pir, Pinar ^{[2
]}

Soldatova, Larisa N. ^{[1
]}

Sparkes, Andrew ^{[1
]}

Whelan, Kenneth E. ^{[1
]}

Clare, Amanda ^{[1
]}

机构：

[1] Aberystwyth Univ, Dept Comp Sci, Aberystwyth SY23 3DB, Dyfed, Wales

[2] Univ Cambridge, Dept Biochem, Cambridge Syst Biol Ctr, Cambridge CB2 1GA, England

[3] Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3DD, Dyfed, Wales

来源：

SCIENCE | 2009年 / 324卷 / 5923期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

ONTOLOGY; GROWTH;

D O I：

10.1126/science.1165620

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.

引用

页码：85 / 89

页数：5

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