Expanding role of AMPK in endocrinology

被引：172

作者：

Kola, Blerina

Boscaro, Marco

Rutter, Guy A.

Grossman, Ashley B.

Korbonits, Marta ^{[1
]}

机构：

[1] Univ London, Barts & London Queen Marys Sch Med & Dent, Dept Endocrinol, London EC1M 6BQ, England

[2] Univ Ancona, Div Endocrinol, Dept Internal Med, Ancona, Italy

[3] Univ Bristol, Sch Med Sci, Dept Biochem, Bristol BS8 1TD, Avon, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/j.tem.2006.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenosine 5' monophosphate-activated protein kinase (AMPK) is a regulator of cellular and systemic energy homeostasis. It mediates some of the effects of peripheral hormones such as leptin, ghrelin and adiponectin, and it is involved in the insulin-sensitizing role of the antidiabetic drug metformin. There is increasing evidence that AMPK has a central role in mediating the appetite-modulating and metabolic effects of many other hormones and substances, including the cannabinoids. Recent studies have illustrated the interaction between hormones and AMPK, and highlighted AMPK as a potential target for the development of tissuespecific AMPK modulators in the treatment of obesity and the metabolic syndrome.

引用

收藏

页码：205 / 215

页数：11

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