Nanoscale ZnO-enhanced fluorescence detection of protein interactions

被引：163

作者：

Dorfman, Adam ^{[1
]}

Kumar, Nitin ^{[1
]}

Hahm, Jong-in ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem Engn, University Pk, PA 16802 USA

来源：

ADVANCED MATERIALS | 2006年 / 18卷 / 20期

关键词：

D O I：

10.1002/adma.200502616

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enhanced fluorescence emission is detected from interacting protein pairs of dichlorotriazinylaminofluoresceinstreptavidin and biotinylated bovine serum albumin (see figure) that are adsorbed onto periodically spaced, square-patterned ZnO nanostructures. This florescence-enhancement capability of nanoscale ZnO and its potential easy integration into biosensor arrays may allow ultrasensitive protein detection, which is needed in the areas of biomedical research and in large-scale testing and screening.

引用

页码：2685 / +

页数：7

共 39 条

[1] Metal-enhanced fluorescence solution-based sensing platform
Aslan, K
Lakowicz, JR
Szmacinski, H
Geddes, CD
[J]. JOURNAL OF FLUORESCENCE, 2004, 14 (06) : 677 - 679
[2] Measuring the work function at a nanobelt tip and at a nanoparticle surface
Bai, XD
Wang, EG
Gao, PX
Wang, ZL
[J]. NANO LETTERS, 2003, 3 (08) : 1147 - 1150
[3] Quantum dots in biology and medicine
Bailey, RE
Smith, AM
Nie, SM
[J]. PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES, 2004, 25 (01) : 1 - 12
[4] EXPERIMENTAL STUDIES ON SPECTRAL SENSITIZATION OF PHOTOCONDUCTIVITY ON ZINC-OXIDE CRYSTALS
BAUER, W
[J]. JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 1977, 38 (05) : 463 - 467
[5] Investigation of the multiple anchors approach in oligonucleotide microarray preparation using linear and stem-loop structured probes
Bordoni, R
Consolandi, C
Castiglioni, B
Busti, E
Bernardi, LR
Battaglia, C
De Bellis, G
[J]. NUCLEIC ACIDS RESEARCH, 2002, 30 (08) : E34 - 34
[6] Semiconductor nanocrystals as fluorescent biological labels
Bruchez, M
Moronne, M
Gin, P
Weiss, S
Alivisatos, AP
[J]. SCIENCE, 1998, 281 (5385) : 2013 - 2016
[7] Highly sensitive biomolecular fluorescence detection using nanoscale ZnO platforms
Dorfman, Adam
Kumar, Nitin
Hahm, Jong-in
[J]. LANGMUIR, 2006, 22 (11) : 4890 - 4895
[8] Single-mismatch detection using gold-quenched fluorescent oligonucleotides
Dubertret, B
Calame, M
Libchaber, AJ
[J]. NATURE BIOTECHNOLOGY, 2001, 19 (04) : 365 - 370
[9] Ferrarini M, 2001, STUD FRANCESI, V45, P155
[10] Metal-enhanced fluorescence
Geddes, CD
Lakowicz, JR
[J]. JOURNAL OF FLUORESCENCE, 2002, 12 (02) : 121 - 129

← 1 2 3 4 →