Highly enantioselective copper-catalyzed 1,4-conjugate addition of diethylzinc to cyclic enones and α,β-unsaturated lactones

被引：25

作者：

Liang, L

Yan, M

Li, YM

Chan, ASC ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[3] Guangdong Univ Technol, Fac Chem Engn & Light Ind, Guangzhou 510090, Peoples R China

[4] Suzhou Univ, Dept Chem & Chem Engn, Suzhou 215006, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 16期

关键词：

D O I：

10.1016/j.tetasy.2004.07.012

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A significant improvement in enantioselectivity has been achieved in the 1,4-additions of diethylzinc to 2-cyclopentenone, 2-cyclohexenone and 5,6-hydro-2H-pyran-2-one (up to 93%, 98% and 94% ee, respectively) by using a chiral diphosphite-copper catalyst under suitable reaction conditions. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2575 / 2578

页数：4

共 31 条

[1]

Alexakis A, 2000, EUR J ORG CHEM, V2000, P4011, DOI 10.1002/1099-0690(200012)2000:24<4011::AID-EJOC4011>3.0.CO

[2]

2-D

[3] Acceleration of the conjugate addition of diethyl zinc to enones by either Cu(OTf)(2) or trivalent phosphorus ligands [J].