The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells

被引：29

作者：

Arulampalam, V

Eckhardt, L

Pettersson, S

机构：

[1] CUNY HUNTER COLL,DEPT BIOL SCI,NEW YORK,NY 10021

[2] KAROLINSKA INST,DEPT BIOSCI,S-14157 HUDDINGE,SWEDEN

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(97)01154-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The roles attributed to the E mu enhancer and the downstream 3' regions acting as locus control regions (LCRs) have allowed comparisons to be drawn between regulation of the IgH locus in early and late B-cell development and other systems governed by LCR activity. Here, the importance of the IgH 3'LCR and its putative functional role in the control of IgH gene expression is evaluated and compared with the 5'LCR regulatory region of the human beta-globin locus.

引用

页码：549 / 554

页数：6

共 60 条

[51] STAUDT LM, 1991, ANNU REV IMMUNOL, V9, P373
[52] Steger David J., 1996, Bioessays, V18, P875, DOI 10.1002/bies.950181106
[53] OBF-1, A NOVEL B-CELL-SPECIFIC COACTIVATOR THAT STIMULATES IMMUNOGLOBULIN PROMOTER ACTIVITY THROUGH ASSOCIATION WITH OCTAMER-BINDING PROTEINS
STRUBIN, M
NEWELL, JW
MATTHIAS, P
[J]. CELL, 1995, 80 (03) : 497 - 506
[54] THE IMMUNOGLOBULIN HEAVY-CHAIN ENHANCER FUNCTIONS AS THE PROMOTER FOR I-MU STERILE TRANSCRIPTION
SU, LK
KADESCH, T
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (06) : 2619 - 2624
[55] HUMAN GLOBIN LOCUS ACTIVATION REGION (LAR) - ROLE IN TEMPORAL CONTROL
TOWNES, TM
BEHRINGER, RR
[J]. TRENDS IN GENETICS, 1990, 6 (07) : 219 - 223
[56] EXPRESSION OF IMMUNOGLOBULIN HEAVY-CHAIN AT A HIGH-LEVEL IN THE ABSENCE OF A PROPOSED IMMUNOGLOBULIN ENHANCER ELEMENT IN CIS
WABL, MR
BURROWS, PD
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (08): : 2452 - 2455
[57] TRANSCRIPTION COMPLEX STABILITY AND CHROMATIN DYNAMICS IN-VIVO
WIJGERDE, M
GROSVELD, F
FRASER, P
[J]. NATURE, 1995, 377 (6546) : 209 - 213
[58] REPLACEMENT OF GERM-LINE EPSILON-PROMOTER BY GENE TARGETING ALTERS CONTROL OF IMMUNOGLOBULIN HEAVY-CHAIN CLASS SWITCHING
XU, LX
GORHAM, B
LI, SC
BOTTARO, A
ALT, FW
ROTHMAN, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (08) : 3705 - 3709
[59] A SELECTIVE DEFECT IN IGG2B SWITCHING AS A RESULT OF TARGETED MUTATION OF THE I-GAMMA-2B PROMOTER AND EXON
ZHANG, J
BOTTARO, A
LI, S
STEWART, V
ALT, FW
[J]. EMBO JOURNAL, 1993, 12 (09) : 3529 - 3537
[60] THE POU DOMAINS OF THE OCT1 AND OCT2 TRANSCRIPTION FACTORS MEDIATE SPECIFIC INTERACTION WITH TBP
ZWILLING, S
ANNWEILER, A
WIRTH, T
[J]. NUCLEIC ACIDS RESEARCH, 1994, 22 (09) : 1655 - 1662

← 1 2 3 4 5 6 →