Apoptosis and necrosis: Intracellular ATP level as a determinant for cell death modes

被引：269

作者：

Tsujimoto, Y

机构：

[1] Osaka University, Medical School, Biomedical Research Center, Suita

来源：

CELL DEATH AND DIFFERENTIATION | 1997年 / 4卷 / 06期

关键词：

ATP; necrosis; apoptosis; mitochondria; bcl-2; caspase;

D O I：

10.1038/sj.cdd.4400262

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis and necrosis are two distinct modes of cell death with respective morphological characteristics. However, apoptosis and some forms of necrosis must share common steps since both modes of cell death can be suppressed by the anti-apoptotic Bcl-2 protein and caspase inhibitors. Intracellular ATP levels have been implicated both in vitro and in vivo as a determinant of the cell's decision to die by apoptosis or necrosis.

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页码：429 / 434

页数：6

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