KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL

被引：43

作者：

Guan, Feng ^{[1
]}

Kang, Zhuang ^{[2
]}

Zhang, Jun-Ting ^{[2
]}

Xue, Ni-Na ^{[3
]}

Yin, Hui ^{[4
]}

Wang, Liang ^{[2
]}

Mao, Bei-Bei ^{[1
]}

Peng, Wei-Cheng ^{[1
]}

Zhang, Bo-Lun ^{[1
]}

Liang, Xin ^{[1
]}

Hu, Zhi-Qiang ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Neurosurg, Beijing, Peoples R China

[2] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Mat Med, Beijing, Peoples R China

[4] Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 514卷 / 01期

关键词：

Glioma; KLF7; ASL; Polyamine; KRUPPEL-LIKE FACTORS; ARGININOSUCCINATE LYASE; 3; FINGERS; CANCER; EXPRESSION;

D O I：

10.1016/j.bbrc.2019.04.120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Kruppel-like factors (KLFs) are zinc-finger transcriptional factors that regulate target gene expression. Recent studies have shown that KLFs play essential roles in cancer development, whereas the function of KLF7 in glioma remains unclear. In this study, we showed that KLF7 was up-regulated in glioma tissues and its expression was inversely correlated with the patients' survival. Functional experiments demonstrated that KLF7 promoted the proliferation, migration and tumorigenesis of glioma cells. Mechanistically, KLF7 transcriptionally activated argininosuccinate lyase (ASL), which was observed highly expressed in glioma tissues. The biosynthesis of polyamine, a urea cycle metabolite, was enhanced by KLF7 in glioma cells. In addition, ASL contributed to the growth of glioma cells triggered by KLF7. Our findings demonstrate KLF7 as an oncogene and link KLF7 to ASL-mediated polyamine metabolism in glioma. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：51 / 57

页数：7

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