The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach

被引：312

作者：

Stubbings, George ^{[1
]}

Bigwood, Timothy ^{[1
]}

机构：

[1] Cent Sci Lab, York YO41 1LZ, N Yorkshire, England

来源：

ANALYTICA CHIMICA ACTA | 2009年 / 637卷 / 1-2期

关键词：

Liquid chromatography tandem mass spectrometry; QUick; Easy; CHeap; Effective; Rugged and Safe; Ionophores; Sulphonamides; Fluoroquinolones; Quinolones; Nitroimidazoles; Dicarbanilide; Multiresidue; Multiclass; Dispersive solid phase extraction; SOLID-PHASE EXTRACTION; MULTIRESIDUE METHOD; MILK; CONFIRMATION; MATRICES; PRODUCE; MUSCLE; MEAT; MS;

D O I：

10.1016/j.aca.2009.01.029

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel rapid multiresidue/multiclass procedure with liquid chromatography tandem mass spectrometry (LC-MS/MS) detection has been developed to screen for the presence of veterinary drug residues in animal tissues. The method uses a new sample preparation procedure loosely based on QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) methodology. Validation to date has been restricted to chicken muscle and has been performed according to European Commission guidelines [COMMISSION DECISION of 12 August 2002 implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results] for nitroimidazoles, sulphonamides, fluoroquinolones, quinolones, ionophores and dinitrocarbanilide. Recent work has shown that the method is also applicable to macrolide and lincosamide antibiotics. benzimidazoles, levamisole, avermectins and tranquillisers. Crown Copyright (c) 2009 Published by Elsevier B.V. All rights reserved.

引用

页码：68 / 78

页数：11

共 16 条

[1] Multi-residue determination of veterinary drugs in milk by ultra-high-pressure liquid chromatography-tandem mass spectrometry [J].