Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA

被引：121

作者：

Foster, MP

Wuttke, DS

Radhakrishnan, I

Case, DA

Gottesfeld, JM

Wright, PE

机构：

[1] Scripps Res Inst, SKAGGS INST CHEM BIOL, LA JOLLA, CA 92037 USA

[2] Scripps Res Inst, DEPT MOL BIOL, LA JOLLA, CA 92037 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 08期

关键词：

D O I：

10.1038/nsb0897-605

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.

引用

页码：605 / 608

页数：4

共 38 条

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