An efficient synthesis of chiral homophenylalanine derivatives via enantioselective hydrogenation

被引：28

作者：

Li, XS

Yeung, CH ^{[1
]}

Chan, ASC

Lee, DS

Yang, TK

机构：

[1] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

[3] Natl Chung Hsing Univ, Dept Chem, Taichung 40227, Taiwan

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(99)00424-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral homophenylalanine derivatives were synthesized via enantioselective hydrogenation of 5a and 5b catalyzed by rhodium complexes bearing chiral phosphine and phosphinite legands. Enantiomeric excesses up to 96.2% were achieved when S-spiroOP(S-1) was used as a chiral ligand under 500 psi of H-2 pressure in acetone. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3863 / 3867

页数：5

共 17 条

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AKIYAMA Y, 1984, CHEM PHARM BULL, V32, P1800

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