Zinc triflate-bis-oxazoline complexes as chiral catalysts:: enantioselective reduction of α-alkoxy-ketones with catecholborane

被引：44

作者：

Bandini, M ^{[1
]}

Cozzi, PG ^{[1
]}

de Angelis, M ^{[1
]}

Umani-Ronchi, A ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期

关键词：

asymmetric reactions; catalysis; ketones; reduction;

D O I：

10.1016/S0040-4039(99)02339-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new methodology for the catalytic enantioselective reduction of oc-alkoxy-ketones is described. The procedure employes Zn(OTf)(2)-bis-oxazoline complexes (8-10 mol%) as catalysts and catecholborane as the reducing agent. The reaction, carried out in CH2Cl2 at 0 degrees C, affords the alpha-alkoxy-alcohols in high yields and with good enantioselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1601 / 1605

页数：5

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