New antibacterial diterpenes from Pseudopterogorgia elisabethae

被引：42

作者：

Ata, A

Win, HY

Holt, D

Holloway, P

Segstro, EP

Jayatilake, GS

机构：

[1] Univ Winnipeg, Dept Chem, Winnipeg, MB R3B 2E9, Canada

[2] Hauser Inc, Denver, CO 80221 USA

[3] Univ Winnipeg, Dept Biol, Winnipeg, MB R3B 2E9, Canada

来源：

HELVETICA CHIMICA ACTA | 2004年 / 87卷 / 05期

关键词：

D O I：

10.1002/hlca.200490099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

From the MeOH extract of Pseudopterogorgia elisabethae, collected from the Bahamas, four new diterpenes, elisabethin E (1), elisabethin F (2), pseudopterosin P (3), and pseudopterosin Q (4), were isolated and their structures established with the aid of extensive spectroscopic studies. Compounds 3 and 4 showed antibacterial activity selectively against the Gram-positive bacteria Streptococcus pyogenes, Staphylococcus aureus, and Enterococcus faecalis.

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收藏

页码：1090 / 1098

页数：9

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