Movin' on up:: the role of Ptdlns(4,5)P2 in cell migration

被引：117

作者：

Ling, Kun

Schill, Nicholas J.

Wagoner, Matthew P.

Sun, Yue

Anderson, Richard A.

机构：

[1] Univ Wisconsin, Sch Med, Dept Pharmacol, Program Mol & Cellular Pharmacol, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Med, Dept Pharmacol, Program Mol & Mol Biol, Madison, WI 53706 USA

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tcb.2006.03.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell migration requires the coordination of many biochemical events, including cell-matrix contact turnover and cytoskeletal restructuring. Recent advances further implicate phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P-2] in the control of these events. Many proteins that are crucial to the assembly of the migration machinery are regulated by PtdIns(4,5)P-2. Coordinated synthesis of PtdIns(4,5)P-2 at these sites is dependent on the precise targeting of the type I phosphatidylinositol phosphate kinases (PIPKs). Two PIPKI isoforms target to, and generate, PtdIns(4,5)P-2 at membrane ruffles and focal adhesions during cell migration. Here, we discuss our current understanding of PtdIns(4,5)P-2 in the regulation of cell responses to migratory stimuli and how the migrating cell controls PtdIns(4,5)P-2 availability.

引用

收藏

页码：276 / 284

页数：9

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