Chiral Bronsted acid catalyzed enantioselective aza-Diels-Alder reaction of Brassard's diene with imines

被引：192

作者：

Itoh, Junji ^{[1
]}

Fuchibe, Kohei ^{[1
]}

Akiyama, Takahiko ^{[1
]}

机构：

[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 29期

关键词：

asymmetric synthesis; aza-Diels-Alder reaction; Bronsted acids; enantioselectivity; organocatalysis;

D O I：

10.1002/anie.200601345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Brønsted, Brassard, Diels, and Alder: Aldimines 1 undergo aza-Diels-Alder reactions with Brassard's diene 2 in the presence of a chiral cyclic phosphate pyridinium salt 4 as a chiral Brønsted acid to give α,β-unsaturated δ-lactams 3 with excellent enantioselectivity. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4796 / 4798

页数：3

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