Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines

被引：19

作者：

Brenner, E ^{[1
]}

Schneider, R ^{[1
]}

Fort, Y ^{[1
]}

机构：

[1] Univ Nancy 1, UMR CNRS 7565, Fac Sci Synthese Organ & Reactivite, F-54506 Vandoeuvre Les Nancy, France

来源：

TETRAHEDRON | 2002年 / 58卷 / 34期

关键词：

N-arylation; N; '-diarylation; secondary diamines; nickel catalysis;

D O I：

10.1016/S0040-4020(02)00750-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The selective synthesis of N-aryl or N,N'-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2'-bipyridine is described. The Ni/2,2'-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：6913 / 6924

页数：12

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