Editorial:: Phenotypic consequences of the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism:: The weight of the evidence in genetic association studies

被引:8
作者
Florez, JC
机构
[1] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[4] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02141 USA
[5] MIT, Cambridge, MA 02141 USA
[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
关键词
D O I
10.1210/jc.2004-1402
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4234 / 4237
页数:4
相关论文
共 20 条
[1]   The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[2]   Candidate gene association study in type 2 diabetes indicates a role for genes involved in β-cell function as well as insulin action [J].
Barroso, I ;
Luan, J ;
Middelberg, RPS ;
Harding, AH ;
Franks, PW ;
Jakes, RW ;
Clayton, D ;
Schafer, AJ ;
O'Rahilly, S ;
Wareham, NJ .
PLOS BIOLOGY, 2003, 1 (01) :41-55
[3]   The human peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes [J].
Caramori, ML ;
Canani, LH ;
Costa, LA ;
Gross, JL .
DIABETES, 2003, 52 (12) :3010-3013
[4]   Mapping complex disease loci in whole-genome association studies [J].
Carlson, CS ;
Eberle, MA ;
Kruglyak, L ;
Nickerson, DA .
NATURE, 2004, 429 (6990) :446-452
[5]   A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity [J].
Deeb, SS ;
Fajas, L ;
Nemoto, M ;
Pihlajamäki, J ;
Mykkänen, L ;
Kuusisto, J ;
Laakso, M ;
Fujimoto, W ;
Auwerx, J .
NATURE GENETICS, 1998, 20 (03) :284-287
[6]   Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region [J].
Florez, JC ;
Burtt, N ;
de Bakker, PIW ;
Almgren, P ;
Tuomi, T ;
Holmkvist, J ;
Gaudet, D ;
Hudson, TJ ;
Schaffner, SF ;
Daly, MJ ;
Hirschhorn, JN ;
Groop, L ;
Altshuler, D .
DIABETES, 2004, 53 (05) :1360-1368
[7]   The inheritebasis odiabetes mellitus: Implications for the genetic analysis of complex traits [J].
Florez, JC ;
Hirschhorn, J ;
Altshuler, D .
ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2003, 4 :257-291
[8]   Large-scale association studies of variants in genes encoding the pancreatic β-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes [J].
Gloyn, AL ;
Weedon, MN ;
Owen, KR ;
Turner, MJ ;
Knight, BA ;
Hitman, G ;
Walker, M ;
Levy, JC ;
Sampson, M ;
Halford, S ;
McCarthy, MI ;
Hattersley, AT ;
Frayling, TM .
DIABETES, 2003, 52 (02) :568-572
[9]   Peroxisome proliferator-activated receptor-γ2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes -: The Berlin Diabetes Mellitus (BeDiaM) Study [J].
Herrmann, SM ;
Ringel, J ;
Wang, JG ;
Staessen, JA ;
Brand, E .
DIABETES, 2002, 51 (08) :2653-2657
[10]   A comprehensive review of genetic association studies [J].
Hirschhorn, JN ;
Lohmueller, K ;
Byrne, E ;
Hirschhorn, K .
GENETICS IN MEDICINE, 2002, 4 (02) :45-61