Editorial:: Phenotypic consequences of the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism:: The weight of the evidence in genetic association studies

被引:8
作者
Florez, JC
机构
[1] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA
[4] Harvard Univ, Broad Inst, Program Med & Populat Genet, Cambridge, MA 02141 USA
[5] MIT, Cambridge, MA 02141 USA
[6] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
关键词
D O I
10.1210/jc.2004-1402
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:4234 / 4237
页数:4
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共 20 条
[11]   Peroxisome proliferator-activated receptor γ:: Implications for cardiovascular disease [J].
Hsueh, WA ;
Bruemmer, D .
HYPERTENSION, 2004, 43 (02) :297-305
[12]   Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease [J].
Lohmueller, KE ;
Pearce, CL ;
Pike, M ;
Lander, ES ;
Hirschhorn, JN .
NATURE GENETICS, 2003, 33 (02) :177-182
[13]   Effect of the peroxisome proliferator activated receptor-γ gene Pro12Ala variant on body mass index:: a metaanalysis [J].
Masud, S ;
Ye, S .
JOURNAL OF MEDICAL GENETICS, 2003, 40 (10) :773-780
[14]   The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes [J].
Nielsen, EMD ;
Hansen, L ;
Carstensen, B ;
Echwald, SM ;
Drivsholm, T ;
Glümer, C ;
Thorsteinsson, B ;
Borch-Johnsen, K ;
Hansen, T ;
Pedersen, O .
DIABETES, 2003, 52 (02) :573-577
[15]   Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction [J].
Ridker, PM ;
Cook, NR ;
Cheng, S ;
Erlich, HA ;
Lindpaintner, K ;
Plutzky, J ;
Zee, RYL .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (05) :859-863
[16]   Are variants in the CAPN10 gene related to risk of type 2 diabetes?: A quantitative assessment of population and family-based association studies [J].
Song, YQ ;
Niu, TH ;
Manson, JAE ;
Kwiatkowski, DJ ;
Liu, SM .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 74 (02) :208-222
[17]   PPAR-γ:: Adipogenic regulator and thiazolidinedione receptor [J].
Spiegelman, BM .
DIABETES, 1998, 47 (04) :507-514
[18]   Ala12Ala genotype of the peroxisome proliferator-activated receptor γ2 protects against atherosclerosis [J].
Temelkova-Kurktschiev, T ;
Hanefeld, M ;
Chinetti, G ;
Zawadzki, C ;
Haulon, S ;
Kubaszek, A ;
Koehler, C ;
Leonhardt, W ;
Staels, B ;
Laakso, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4238-4242
[19]   Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility [J].
Weedon, MN ;
Schwarz, PEH ;
Horikawa, Y ;
Iwasaki, N ;
Illig, T ;
Holle, R ;
Rathmann, W ;
Selisko, T ;
Schulze, J ;
Owen, KR ;
Evans, J ;
Bosque-Plata, LD ;
Hitman, G ;
Walker, M ;
Levy, JC ;
Sampson, M ;
Bell, GI ;
McCarthy, MI ;
Hattersley, AT ;
Frayling, TM .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (05) :1208-1212
[20]   Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians:: Identification of a Pro12Ala PPARγ2 missense mutation [J].
Yen, CJ ;
Beamer, BA ;
Negri, C ;
Silver, K ;
Brown, KA ;
Yarnall, DP ;
Burns, DK ;
Roth, J ;
Shuldiner, AR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (02) :270-274